Publications

2024

  • Intra-fractional geometric and dose/volume metric variations of magnetic resonance imaging-guided stereotactic radiotherapy of prostate bed after radical prostatectomy Yu Gao, Stephanie Yoon, Ting Martin Ma, Yingli Yang, Ke Sheng, Daniel A. Low, Leslie Ballas, Michael L. Steinberg, Amar U Kishan, Minsong Cao, Physics and Imaging in Radiation Oncology, 2024, DOI:https://doi.org/10.1016/j.phro.2024.100573
  • Nodule detection and generation on chest X-rays: NODE21 Challenge, Ecem Sogancioglu, Bram van Ginneken, Finn Behrendt, Marcel Bengs, Alexander Schlaefer, Miron Radu, Di Xu, Ke Sheng, Fabien Scalzo, Eric Marcus, Samuele Papa, Jonas Teuwen, Ernst Th. Scholten, Steven Schalekamp, Nils Hendrix, Colin Jacobs, Ward Hendrix, Clara I S ́anchez, Keelin Murphy IEEE Transaction on Medical Imaging 2024 https://ieeexplore.ieee.org/document/10479589
  • Deep Match: A Zero-Shot Data-Robust Framework for Improved Fiducial-free Lung Tumor Motion Tracking, Di Xu, Martina Descovich, Hengjie Liu, Yi Lao, Alexander R. Gottschalk, Ke Sheng, Radiotherapy and Oncology 2024 https://www.thegreenjournal.com/article/S0167-8140(24)00100-2/abstract
  • Hypoxia-informed RBE-weighted beam orientation optimization for intensity-modulated proton therapy, Pavitra Ramesh, Dan Ruan, S. John Liu, Youngho Seo, Steve Braunstein, and Ke Sheng, Medical Physics 2024, https://doi.org/10.1002/mp.16978
  • Robust Treatment Planning for Small Animal Radio-Neuromodulation Using Focused kV X-ray Beams, Chenhui Qiu, Wenbo Gu, Huagang Yan, Weiyuan Sun, Yuanyuan Wang, Qiang Wen, Ke Sheng, Wu Liu, Medical Physics 2024 DOI: 10.1002/mp.17023
  • Dosimetric Predictors for Acute Genitourinary Toxicity in MR-guided Stereotactic Body Radiation Therapy (SBRT): Expanded Substructure with Fraction-wise Analysis, Jonathan Pham, Beth K. Neilsen, Hengjie Liu, Minsong Cao, Yingli Yang, Ke Shen, Ting Martin Ma, Amar U. Kishan, Dan Ruan, Medical Physics 2024 https://doi.org/10.1002/mp.16878

2023

  • Dosimetric Impact of Interfractional Bladder and Trigone Deformations: A Post-Hoc Analysis of a Phase III Randomized Trial of MRI-Guided vs. CT-Guided Stereotactic Body Radiotherapy in Prostate Cancer Beth K. Neilsen, Ting Martin Ma, Wisdom O. Akingbemi, John P. Neylon, Maria Casado, Sahil Sharma, Ke Sheng, Dan Ruan, Daniel Low, Yingli Yang, Luca F. Valle, Michael L Steinberg, James M. Lamb, Minsong Cao, Amar U. Kishan, International Journal of Radiation Oncology Biology and Physics 2023 https://doi.org/10.1016/j.ijrobp.2022.07.1197
  • A Unified Path Seeking Algorithm for IMRT and IMPT Beam Orientation Optimization, Pavitra Ramesh, Gilmer Valdes, Daniel O'Connor, Ke Sheng, Physics in Medicine and Biology 2023 https://doi.org/10.1088/1361-6560/acf63f.
  • Minimum Reporting Standards Should be Expected for Preclinical Radiobiology Irradiators and Dosimetry in the Published Literature, Poirier Y, DeWerd LA, Trompier F, Santos MD, Sheng K, Kunugi K, Satyamitra MM, DiCarlo AL, Winters TA,  Radiat Res. 2023 Aug 8. doi: 10.1667/RADE-23-00119.1.
    • Also appear in International Journal of Radiation Biology 2023 https://doi.org/10.1080/09553002.2023.2250848
  • Contrast-enhanced Liver MR Synthesis using Gradient Regularized Multi-Modal Multi-Discrimination Sparse Attention Fusion GAN Changzhe Jiao, Diane Ling, Shelly Bian, April Vassantachart, Karen Cheng, Shahil Mehta, Derrick Lock, Zhenyu Zhu, Mary Feng, Horatio Thomas, Jessica E Scholey, Ke Sheng, Zhaoyang Fan, Wensha Yang, Cancers, 2023 Jul 8;15(14):3544. doi: 10.3390/cancers15143544.
  • Gell: A GPU-powered 3D hybrid simulator for large-scale multicellular system, Jiayi Du, Yu Zhou, Lihua Jin, Ke Sheng, Plos ONE, 2023 Jul 18;18(7):e0288721. doi: 10.1371/journal.pone.0288721
  • An Efficient and Robust Method for Chest X-ray Rib Suppression That Improves Pulmonary Abnormality Diagnosis Di Xu, Qifan Xu, Kevin Nhieu, Dan Ruan, Ke Sheng, Diagnostics (Basel) 2023 May 8;13(9):1652. doi: 10.3390/diagnostics13091652.
  • Technical Note: Multi-MATE, A High-Throughput Platform For Automated Image-Guided Small-Animal Irradiation Jiang Lu, Pavitra Ramesh, Ryan Neph, Ke Sheng, Medical Physics 2023 https://doi.org/10.1002/mp.16563
  • Analytical HDR Prostate Brachytherapy Planning with Automatic Catheter and Isotope Selection, C Holly Frank, Pavitra Ramesh, Qihui Lyu, Dan Ruan, Sangjune Park, Albert Chang, Puja Venkat, Amar U Kishan, Ke Sheng, Medical Physics 2023 http://doi.org/10.1002/mp.16677 
  • Transformative Technology for FLASH Radiation Therapy Reinhard Schulte, Carol Johnstone, Salime Boucher, Eric Esarey, Cameron G. R. Geddes, Maksim Kravchenko, Sergey Kutsaev, Billy W. Loo, François Méot, Brahim Mustapha, Kei Nakamura, Emilio A. Nanni, Lieselotte Obst-Huebl, Stephen E. Sampayan, Carl B. Schroeder, Ke Sheng, Antoine M. Snijders, Emma Snively, Sami G. Tantawi and Jeroen Van Tilborg Appl. Sci. 2023, 13(8), 5021; https://doi.org/10.3390/app13085021
  • Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing, Qihui Lyu, Ryan Neph, Ke Sheng*, Nat Biomed Eng. 2023 Mar;7(3):323-334. doi: 10.1038/s41551-022-00953-8.2022 https://www.nature.com/articles/s41551-022-00953-8
  • Magnetic resonance imaging-guided versus computed tomography-guided stereotactic body radiotherapy for prostate cancer (MIRAGE): Primary Endpoint Analysis of a Phase III Randomized Trial Amar U. Kishan Ting Martin Ma, James M. Lamb, Maria Casado, Holly Wilhalme, Daniel A. Low, Ke Sheng, Sahil Sharma, Yingli Yang, Yu Gao, John Neylon, Vincent Basehart, Minsong Cao, Michael L. Steinberg JAMA Oncol. 2023 Jan 12. doi: 10.1001/jamaoncol.2022.6558
  • Mask R-CNN Assisted 2.5D Object Detection Pipeline of 68Ga-PSMA-11 PET/CT-positive Metastatic Pelvic Lymph Node After Radical Prostatectomy from solely CT Imaging, Di Xu, Martin Ma, Minsong Cao, Amar U. Kishan, Nicholas G. Nickols, Fabien Scalzo and Ke Sheng, Nat. Scientific Reports https://rdcu.be/c4sMd DOI:10.1038/s41598-023-28669-y

2022

  • Gell: A GPU-powered 3D hybrid simulator for large-scale multicellular system Jiayi Du, Yu Zhou, Lihua Jin, Ke Sheng,  https://www.biorxiv.org/content/10.1101/2022.09.01.506296v1 doi.org/10.1101/2022.09.01.506296
  • Dose and dose rate objectives in Bragg peak and shoot-through beam orientation optimization for FLASH proton therapy, Pavitra Ramesh, Wenbo Gu, Dan Ruan, Ke Sheng, Medical Physics, Med Phys. 2022 Oct 12. doi: 10.1002/mp.1600
  • An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation Lu Jiang, Qihui Lyu, Amr M H Abdelhamid, Susanta Hui, Ke Sheng, Physics and Medicine in Biology,  2022, doi:10.1088/1361-6560/ac910b
  • Evaluation of T2-Weighted MRI for Visualization and Sparing of Urethra with MR-Guided Radiation Therapy (MRgRT) On-Board MRI. Pham J, Savjani RR, Gao Y, Cao M, Hu P, Sheng K, Low DA, Steinberg M, Kishan AU, Yang Y. Cancers (Basel). 2021 Jul 16;13(14):3564. doi: 10.3390/cancers13143564.
  • Fully Automated Segmentation of Prostatic Urethra for MR-Guided Radiation Therapy (MRgRT), Di Xu, Ting Martin Ma, Ricky Savjani, Jonathan Pham, Minsong Cao, Yingli Yang, Amar U. Kishan, Fabien Scalzo, Ke Sheng* Medical Physics 2022 http://doi.org/10.1002/mp.15983
  • Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality Amr M. H. Abdelhamid, Lu Jiang, Darren Zuro, An Liu, Srideshikan Sargur Madabushi, Hemendra Ghimire, Jeffrey Y. C. Wong, Simonetta Saldi, Christian Fulcheri, Claudio Zucchetti, Antonio Pierini, Ke Sheng, Cynthia Aristei and Susanta K. Hui Front. Oncol., 18 July 2022, https://doi.org/10.3389/fonc.2022.941814
  • Reformulated McNamara RBE-weighted Beam Orientation Optimization for Intensity Modulated Proton Therapy, Pavitra Ramesh, Qihui Lyu, Wenbo Gu, Dan Ruan, and Ke Sheng, Med Phys. 2022 Apr;49(4):2136-2149. doi: 10.1002/mp.15552
  • A Prospective Phase II Study of Automated Non-Coplanar VMAT for Recurrent Head and Neck Cancer:  Initial Report of Feasibility, Safety, and Patient Reported Outcomes Kaley Woods Ting Martin Ma, Kelsey Narahara, Zhouhuizi Shen, Eric Morris, Yu Gao, Kiri A. Cook, Ke Sheng, Amar U. Kishan, John V. Hegde, Carol Felix,  Vincent Basehart, Stephen Tenn, Michael Steinberg, Robert K. Chin MD, Minsong Cao Cancers 202214(4), 939; https://doi.org/10.3390/cancers14040939
  • Dosimetric Impact of Interfraction Prostate and Seminal Vesicle Volume Changes and Rotation: A Post-Hoc Analysis of a Phase III Randomized Trial of MRI-Guided versus CT-Guided Stereotactic Body Radiotherapy Ting Martin Ma, Minsong Cao, Jack Neylon, Maria Casado, Sahil Sharma, Ke Sheng, Daniel Low, Yingli Yang, Michael L. Steinberg, James Lamb, Amar U. Kishan, Radiotherapy and Oncology, Volume 167, February 2022, Pages 203-210  https://doi.org/10.1016/j.radonc.2021.12.037 
  • To what extent can Plug-and-Play methods outperform neural networks alone in low-dose CT reconstruction, Qifan Xu, Qihui Lyu, Dan Ruan, Ke Sheng, ISBI 2022 https://arxiv.org/abs/2202.07173

2021

  • Transformative Technology for FLASH Radiation Therapy: A Snowmass 2021 White Paper, S.Boucher, E. Esarey, C.G.R. Geddes, C. Johnstone, S. Kutsaev, B.W. Loo Jr., F. Méot, B. Mustapha, K. Nakamura, E. Nanni, L. Obst-Huebl, S.E. Sampayan, C. Schroeder, R. Schulte, K.Sheng, A. Snijders, E. Snively, S.G. Tantawi, J. van Tilborg, arXiv:2203.11047 https://doi.org/10.48550/arXiv.2203.11047
  • Voxel-wise prediction of recurrent brain GBM via proximity estimation coupled multi-dimensional SVM Yi Lao, Dan Ruan, April Vassantachart, Zhaoyang Fan, Jason C. Ye, Eric L. Chang, Robert Chin, Tania Kaprealian, Gabriel Zada, Mark S Shiroishi,  Ke Sheng, and Wensha Yang, International Journal of Radiation.Oncology.Biology.Physics, 2021 https://doi.org/10.1016/j.ijrobp.2021.12.153
  • Bladder surface dose modeling in prostate cancer radiotherapy: an analysis of motion-induced variations and the cumulative dose across the treatment. Yi Lao, Minsong Cao, Yingli Yang, Amar U. Kishan1, Wensha Yang, Yalin Wang, and Ke Sheng, Med Phys.2021;48:8024–8036, DOI: 10.1002/mp.15326
  • Novel technologies for Linac-based radiotherapy Sergey V. Kutsaev, Salime Boucher, Brahim Mustapha, Ke Sheng Proceedings Volume 11838, Hard X-Ray, Gamma-Ray, and Neutron Detector Physics XXIII; 118380U (2021) https://doi.org/10.1117/12.2595707
  • Clinical assessment of geometric distortion for a 0.35T MR-guided radiotherapy system. Neylon J, Cook KA, Yang Y, Du D, Sheng K, Chin RK, Kishan AU, Lamb JM, Low DA, Cao M. J Appl Clin Med Phys. 2021 Jul 7. doi: 10.1002/acm2.13340. Online ahead of print. PMID: 34231963
  • Fixed Beamline Optimization for Intensity Modulated Carbon-Ion Therapy, Pavitra Ramesh, Hengjie Liu, Wenbo Gu, and Ke Sheng IEEE Transactions on Radiation and Plasma Medical Sciences 2021 DOI:10.1109/TRPMS.2021.3092296
  • Using Neural Networks to Extend Cropped Medical Images for Deformable Registration Among Images with Differing Scan Extents, Elizabeth M. McKenzie, Nuo Tong, Dan Ruan, Minsong Cao, Robert K. Chin, Ke Sheng, Medical Physics 2021 DOI: 10.1002/mp.15039 
  • Magnetic Resonance Imaging-Guided Stereotactic Body Radiotherapy for Prostate Cancer (MIRAGE): A Phase III Randomized Trial, Ting Martin Ma, James M. Lamb, Maria Casado, Xiaoyan Wang, T. Vincent Basehart, Yingli Yang, Daniel Low, Ke Sheng, Nzhde Agazaryan, Nicholas G. Nickols, Minsong Cao, Michael L. Steinberg, Amar U. Kishan BMC Cancer 2021 DOI: 10.1186/s12885-021-08281-x
  • Automated Non-Coplanar VMAT for Dose Escalation in Recurrent Head and Neck Cancer Patients,  Kaley Woods, Robert K. Chin, Kiri A. Cook, Ke Sheng, Amar U. Kishan, John V. Hegde, Stephen Tenn, Michael Steinberg, Minsong Cao, Cancers, 2021 DOI: 10.3390/cancers13081910
  • Yi Lao, Victoria Yu, Anthony Pham, Theodore Wang, Jing Cui, Audrey Gallogly, Eric Chang, Zhaoyang Fan, Tania Kaprealian, Wensha Yang, Ke Sheng*, Quantitative characterization of tumor proximity to stem cell niches: implications on recurrence and survival in GBM patients, Int. J. Radiation Oncology.Biology.Physics 2021 In press DOI: https://doi.org/10.1016/j.ijrobp.2021.02.020
  • Victoria Y. Yu, Dan Nguyen, Daniel O’Connor, Dan Ruan, Tania Kaprealian, Robert Chin, Ke Sheng*, Treating Glioblastoma Multiforme (GBM) with super hyperfractionated radiation therapy: Implication of temporal dose fractionation optimization including cancer stem cell dynamics,  PLOS ONE 2021 https://doi.org/10.1371/journal.pone.0245676
  • Weak Magnetic Fields Enhance the Efficacy of Radiotherapy Advances in Radiation Oncology, Robert Sandstrom, Mark Bryan, Yue Liu, Robin S Elgart, Ke Sheng, Michael Steinberg, William McBride, Daniel Low, Kei Iwamoto, Adv Radiat Oncol. 2021 Jan 16;6(3):100645. doi: 10.1016/j.adro.2021.100645.

2020

  • DeepMC: A Deep Learning Method for Efficient Monte Carlo Beamlet Dose Calculation by Predictive Denoising in Magnetic Resonance-Guided Radiotherapy Ryan Neph, Qihui Lyu, Yangsibo Huang, You Ming Yang, Ke Sheng*, Physics and Medicine in Biology, 2020, DOI: 10.1088/1361-6560/abca01
  • ROAD: ROtational direct Aperture optimization with a Decoupled ring-collimator for FLASH radiotherapy, Lyu, Qihui; Neph, Ryan; O'Connor, Daniel; Ruan, Dan; Boucher, Salime; Sheng, Ke*, Physics and Medicine in Biology, 2020, https://iopscience.iop.org/article/10.1088/1361-6560/abcbd0/meta
  • Multi-task Edge-recalibrated Network for Male Pelvic Multi-Organ Segmentation on CT Images, Tong, Nuo; Gou, Shuiping; Chen, Shuzhe; Yao, Yao; Yang, Shuyuan; Cao, Minsong; Kishan, Amar; Sheng, Ke*, Physics and Medicine in Biology, 2020, DOI: 10.1088/1361-6560/abcad9
  • Automatic detection and segmentation of multiple brain metastases on magnetic resonance image using asymmetric UNet architecture,  Cao, Yufeng; Vassantachart, April; Ye, Jason; Yu, Cheng; Ruan, Dan; Sheng, Ke; Lao, Yi; Shen, Zhilei; Balik, Salim; Bian, Shelly; Zada, Gabriel; Shiu, Almon; Chang, Eric; Yang, Wensha Physics and Medicine in Biology, 2020, DOI: 10.1088/1361-6560/abca53
  • Analysis of Geometric Performance and Dosimetric Impact of using Automatic Contour Segmentation for Radiotherapy Planning, Minsong Cao, Bradley Stiehl, Victoria Yu, Ke Sheng, Amar Kishan, Robert K. Chin, Yingli Yang, Dan Ruan, Frontiers in Oncology 2020 https://doi.org/10.3389/fonc.2020.01762
  • Practical Safety Considerations for Integration of Magnetic Resonance Imaging in Radiation Therapy, Minsong Cao, Brad Stiehl, Victoria Yu, Ke Sheng, Amar Kishan, Robert Chin, Yingli Yang, Dan Ruan, Practical Radiation Oncology, 2020 https://doi.org/10.1016/j.prro.2020.07.008
  • Fraction-Variant Beam Orientation Optimization for Intensity-Modulated Proton Therapy, Wenbo Gu, Daniel O’Connor, Dan Ruan, Wei Zou, Lei Dong, and Ke Sheng, Medical Physics 2020 https://doi.org/10.1002/mp.14340
  • Self-paced DenseNet with Boundary Constraint for Automated Multi-Organ Segmentation on Abdominal CT Images, Tong, Nuo; Gou, Shuiping; Niu, Tianye; Yang, Shuyuan; Sheng, Ke, Physics and Medicine in Biology 2020 65 135011 https://doi.org/10.1088/1361-6560/ab9b57
  • Linear Energy Transfer Weighted Beam Orientation Optimization for Intensity-Modulated Proton Therapy, Wenbo Gu, Dan Ruan, Wei Zou, Lei Dong, and Ke Sheng, Medical Physics 2020 https://doi.org/10.1002/mp.14329
  • Iterative reconstruction of cone-beam breast CT using plug-and-play projected gradient descent Qihui Lyu; Tianye Niu; Dan Ruan; Ke Sheng  Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113124J (16 March 2020); doi: 10.1117/12.2549787
  • Deformable alignment of longitudinal postoperative brain GBM scans using deep learning Yi Lao; Victoria Yu; Eric Chang; Wensha Yang; Ke Sheng Proceedings Volume 11313, Medical Imaging 2020: Image Processing; 113130O (2020) https://doi.org/10.1117/12.2549129
  • Quantifying vascular invasion in pancreatic cancer - a contrast CT based method for surgical resectability evaluation, Lao, Yi; David, John ; Fan, Zhaoyang; Bian, Shelly ; Shiu, Almon ; CHANG, ERIC; Sheng, Ke; Yang, Wensha; Tuli, Richard, Physics and Medicine in Biology, 2020 DOI: 10.1088/1361-6560/ab8106
  • Artificial Intelligence in Radiotherapy: A Technological Review, Ke Sheng, Frontiers of Medicine, 2020 https://doi.org/10.1007/s11684-020-0761-1
  • Self-Channel-and-Spatial-Attention Neural Network for Automated Multi-Organ Segmentation on Head and Neck CT Images, Tong, Nuo; Gou, Shuiping; Qi, Sharon; Yang, Shuyuan; Chin, Robert K.; Sheng, Ke, Physics and Medicine in Biology, 2020 accepted  https://iopscience.iop.org/article/10.1088/1361-6560/ab79c3
  • A Novel Energy Layer Optimization Framework for Spot-Scanning Proton Arc Therapy, Wenbo Gu, Dan Ruan, Qihui Lyu, Wei Zou, Lei Dong, and Ke Sheng, Medical Physics, accepted 2020 https://aapm.onlinelibrary.wiley.com/doi/pdf/10.1002/mp.14083
  • Many-isocenter Optimization for Robotic Radiotherapy, Qihui Lyu, Ryan Neph, Victoria Yu, Ran Ruan, Salime Boucher, Ke Sheng, Phys. Med. Biol. 65 (2020) 045003 (14pp) https://iopscience.iop.org/article/10.1088/1361-6560/ab63b8
  • Image domain multi-material decomposition using single energy CT, Yi Xue, Yangkang Jiang, Pengfei Yang, Lei Xu, Chen Luo, Xi Hu, Jing Wang, Xiuhua Xu, Ke Sheng, Tianye Niu, Physics and Medicine in Biology, accepted 2020, https://iopscience.iop.org/article/10.1088/1361-6560/ab7503

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2000

  • The evolution for various matter perturbations in the expanding universe, Wenbin Lin, Ke Sheng Communication in theoretical physics Vol 34 (2000) 173-178